Abstract |
Hemoglobin and DNA gene analyses were carried out in two Black Canadian families. In Family Q, both the parents and the brother were found to be heterozygotes for alpha-thalassemia-2 with the following alpha-genotypes: -alpha 3.7/alpha alpha, -alpha 4.2/alpha alpha and -alpha 4.2/alpha alpha, respectively. In Family C, the mother was found to be a homozygote for alpha-thalassemia-2 with the alpha-genotype of -alpha 3.7/-alpha 3.7. In both families, the propositi were compound heterozygotes for alpha-thalassemia-2 with the alpha-genotype of -alpha 3.7/-alpha 4.2. The propositus in Family C was also a sickle cell trait carrier. The usefulness of DNA gene analyses in family studies of hemoglobinopathy was discussed.
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Authors | S C Wong, L S Chang, N F Olivieri, A O Poon, M A Ali, D J Groves |
Journal | Hemoglobin
(Hemoglobin)
Vol. 9
Issue 2
Pg. 111-26
( 1985)
ISSN: 0363-0269 [Print] England |
PMID | 4030379
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- DNA
(analysis)
- Erythrocytes
(pathology)
- Genotype
- Hemoglobins
(analysis)
- Heterozygote
- Humans
- Infant
- Male
- Pedigree
- Thalassemia
(blood, genetics, metabolism, pathology)
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