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Hepatitis B virus DNA, HBeAg and delta infection during the course from acute to chronic hepatitis B virus infection.

Abstract
The presence of hepatitis B virus DNA in serum was determined in 57 unselected patients during the course from acute to chronic hepatitis B infection. Forty-six (81%) patients were hepatitis B virus DNA-positive in the first available serum sample. Generally, hepatitis B virus DNA was cleared before or at the same time as HBeAg, but in two patients (4%), hepatitis B virus DNA could be demonstrated after HBeAg clearance. One of the latter patients had hepatitis B virus DNA in the presence of anti-HBe. Both patients became hepatitis B virus DNA-negative. Seven of the hepatitis B virus DNA-positive patients received long-term treatment with prednisone, and three of them continued to be hepatitis B virus DNA positive for more than 10 years. Among the untreated patients hepatitis B virus DNA could be detected for up to 7 years, and 10 patients were hepatitis B virus DNA-positive for three years or more. Twenty-four patients (42%) showed serological signs of delta agent infection. Hepatitis B virus DNA clearance was observed in a significantly higher proportion (87%) of delta-infected patients as compared to patients with no delta infection (45%) (p less than 0.05). In addition patients with delta infection had a significantly increased hepatitis B virus DNA clearance rate as compared to patients without delta markers in their serum (p less than 0.01). In one (8%) delta-infected patient, hepatitis B virus DNA clearance was followed by a fall in transaminases into the normal range as opposed to results in 86% of patients with pure hepatitis B (p less than 0.002).
AuthorsK Krogsgaard, J Aldershvile, P Kryger, P Andersson, J O Nielsen, B G Hansson
JournalHepatology (Baltimore, Md.) (Hepatology) 1985 Sep-Oct Vol. 5 Issue 5 Pg. 778-82 ISSN: 0270-9139 [Print] United States
PMID4029890 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Viral
  • Hepatitis B Antigens
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
Topics
  • Carrier State (immunology)
  • DNA, Viral (analysis, blood)
  • Hepatitis B (immunology, microbiology)
  • Hepatitis B Antigens (analysis)
  • Hepatitis B Surface Antigens (analysis)
  • Hepatitis B e Antigens (analysis)
  • Hepatitis B virus (genetics)
  • Humans
  • Longitudinal Studies
  • Virus Replication

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