Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture.

Abstract

Previous studies showed that a cartilage-derived anti-tumor factor (CATF), which was extracted from bovine cartilage with 1 M guanidine hydrochloride, inhibited the growth of solid sarcoma 180, but not the growth of ascites tumors of sarcoma 180 [Suzuki, F. et al. Jpn. J. Bone Metab., 2, 231-235 (1984)]. This study showed that CATF inhibited the proliferation and DNA synthesis of endothelial cells isolated from bovine pulmonary artery, but not the proliferations of sarcoma 180, L1210 and L cells. These results suggest that CATF has anti-angiogenic properties, thereby inhibiting the growth of solid tumors.

• Authors: M Takigawa, E Shirai, M Enomoto, Y Hiraki, M Fukuya, F Suzuki, T Shiio, Y Yugari
• Journal: Cell biology international reports (Cell Biol Int Rep) Vol. 9 Issue 7 Pg. 619-25 (Jul 1985) ISSN: 0309-1651 [Print] England
• PMID: 4028190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Tissue Extracts

Topics

• Animals
• Antineoplastic Agents (isolation & purification, pharmacology)
• Cartilage (physiology)
• Cattle
• Cell Division (drug effects)
• Cells, Cultured
• DNA Replication (drug effects)
• Endothelium (cytology)
• Kinetics
• L Cells (cytology)
• Leukemia L1210 (pathology)
• Pulmonary Artery (cytology)
• Sarcoma 180 (pathology)
• Tissue Extracts (isolation & purification, pharmacology)