HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Human interferon alpha in malignant lymphoma and Hodgkin's disease. Results of the American Cancer Society trial.

Abstract
Forty-nine patients with non-Hodgkin's lymphoma or Hodgkin's disease were entered into a multi-institutional phase II trial to evaluate the antitumor activity of human interferon alpha, prepared from buffy coats. Interferon alpha was administered intramuscularly in doses of 1 X 10(6) u, 3 X 10(6) u or 9 X 10(6) u daily for 30 days. Objective partial responses were seen in 3 of 18 patients with nodular lymphoma, all at the 9 X 10(6) u dose. Interferon alpha was not observed to be of therapeutic benefit in the other subtypes of non-Hodgkin's lymphoma or Hodgkin's disease. The major toxicities consisted of fatigue, fever, myalgias and weight loss. Serum interferon levels obtained 3 to 4 hours after injection varied widely, even among patients treated at the same dose level. Despite the relatively low doses of interferon used and the brief period of administration, this study extends the earlier observations of the antitumor effect of interferon in nodular lymphoma. These results are discussed in relation to the cumulative experience in human lymphoma using alpha interferons induced in human leukocytes and those produced in bacteria by recombinant DNA techniques.
AuthorsS J Horning, T C Merigan, S E Krown, J U Gutterman, A Louie, J Gallagher, J McCravey, J Abramson, F Cabanillas, H Oettgen
JournalCancer (Cancer) Vol. 56 Issue 6 Pg. 1305-10 (Sep 15 1985) ISSN: 0008-543X [Print] United States
PMID4027869 (Publication Type: Journal Article)
Chemical References
  • Interferon Type I
Topics
  • Adolescent
  • Adult
  • Aged
  • Evaluation Studies as Topic
  • Fatigue (etiology)
  • Female
  • Fever (etiology)
  • Hodgkin Disease (therapy)
  • Humans
  • Interferon Type I (adverse effects, blood, therapeutic use)
  • Lymphoma (therapy)
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: