Abstract |
Food deprivation has been shown to increase intravenous self-administration of amphetamine and cocaine. In the present experiment, the response rates of four groups of eight rats for intravenous infusions of phentermine under free-feeding (FF) and 80% free-feeding weight (FFW) conditions in the presence and absence of a fixed time 1 min (FT-1) food delivery schedule, were compared with those of saline reinforced animals under identical conditions. The findings showed that: (1) Overall, response rates of phentermine-reinforced animals were significantly greater than were those of saline-reinforced animals; (2) 80% FFW animals self-injected significantly greater amounts of phentermine than did FF animals; and (3) the operation of an FT-1 schedule failed to affect the rate of phentermine-reinforced responding.
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Authors | M Papasava, G Singer, C L Papasava |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 22
Issue 6
Pg. 1071-3
(Jun 1985)
ISSN: 0091-3057 [Print] United States |
PMID | 4023024
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Body Weight
- Food
- Male
- Phentermine
(pharmacology)
- Rats
- Rats, Inbred Strains
- Reinforcement Schedule
- Self Administration
- Time Factors
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