Abstract |
Studies on bone metabolism described in a fatal case of acute parathyroid crisis, occurring in a 48-year-old woman in whom serum immunoreactive parathyroid hormone levels were very high, and a 5 g parathyroid adenoma was found at operation. The histological and biochemical findings suggested a massive and acute increase in bone resorption. There was, however, no evidence of any compensatory increase in bone formation, indicating that acute parathyroid crisis is characterized by a marked dissociation between bone resorption and formation. It is suggested that a sudden fall in oestrogen levels may contribute to the pathogenesis of this disorder.
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Authors | T Cundy, A J Darby, H E Berry, V Parsons |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 22
Issue 6
Pg. 787-93
(Jun 1985)
ISSN: 0300-0664 [Print] England |
PMID | 4017262
(Publication Type: Case Reports, Journal Article)
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Topics |
- Acute Disease
- Adenoma
(complications, metabolism)
- Bone Resorption
(metabolism, pathology)
- Bone and Bones
(metabolism, pathology)
- Female
- Humans
- Hypercalcemia
(complications, metabolism)
- Middle Aged
- Parathyroid Diseases
(complications, metabolism)
- Parathyroid Neoplasms
(complications, metabolism)
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