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Bone metabolism in acute parathyroid crisis.

Abstract
Studies on bone metabolism described in a fatal case of acute parathyroid crisis, occurring in a 48-year-old woman in whom serum immunoreactive parathyroid hormone levels were very high, and a 5 g parathyroid adenoma was found at operation. The histological and biochemical findings suggested a massive and acute increase in bone resorption. There was, however, no evidence of any compensatory increase in bone formation, indicating that acute parathyroid crisis is characterized by a marked dissociation between bone resorption and formation. It is suggested that a sudden fall in oestrogen levels may contribute to the pathogenesis of this disorder.
AuthorsT Cundy, A J Darby, H E Berry, V Parsons
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 22 Issue 6 Pg. 787-93 (Jun 1985) ISSN: 0300-0664 [Print] England
PMID4017262 (Publication Type: Case Reports, Journal Article)
Topics
  • Acute Disease
  • Adenoma (complications, metabolism)
  • Bone Resorption (metabolism, pathology)
  • Bone and Bones (metabolism, pathology)
  • Female
  • Humans
  • Hypercalcemia (complications, metabolism)
  • Middle Aged
  • Parathyroid Diseases (complications, metabolism)
  • Parathyroid Neoplasms (complications, metabolism)

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