Abstract |
A study was undertaken on serial measurements of plasma angiotensin I (A-I) and serum placental leucine aminopeptidase (P-LAP) activities in normal and pre-eclamptic pregnancy. There was the significant difference in A-I levels between normal and mild pre-eclamptic pregnancy at weeks 30, 35, 37, between normal and severe pre-eclamptic pregnancy at week 37. There were no differences in serum P-LAP between normal and mild pre-eclamptic pregnancy up to week 33, but thereafter the levels for the mild pre-eclampsia were significantly higher than for the normal pregnancy. The P-LAP activity for the severe pre-eclampsia reached its maximum level at week 31. Around this week, the levels for severe pre-eclampsia were significantly higher than in the normal pregnancy. After week 35, the activities decreased precipitously to week 40; the activities for severe pre-eclampsia in late pregnancy at weeks 39 and 40 were significantly lower than in normal pregnancy. The above data support the idea that P-LAP test is useful for prediction or diagnosis of pre-eclampsia.
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Authors | S Mizutani, H Akiyama, O Kurauchi, H Taira, O Narita, Y Tomoda |
Journal | Archives of gynecology
(Arch Gynecol)
Vol. 236
Issue 3
Pg. 165-72
( 1985)
ISSN: 0170-9925 [Print] Germany |
PMID | 4015192
(Publication Type: Journal Article)
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Chemical References |
- Angiotensins
- Angiotensin I
- Leucyl Aminopeptidase
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Topics |
- Adult
- Angiotensin I
(blood)
- Angiotensins
(blood)
- Female
- Humans
- Infant, Newborn
- Leucyl Aminopeptidase
(blood)
- Placenta
(enzymology)
- Placental Function Tests
- Pre-Eclampsia
(blood, diagnosis, enzymology)
- Pregnancy
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