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Plasma angiotensin I and serum placental leucine aminopeptidase (P-LAP) in pre-eclampsia.

Abstract
A study was undertaken on serial measurements of plasma angiotensin I (A-I) and serum placental leucine aminopeptidase (P-LAP) activities in normal and pre-eclamptic pregnancy. There was the significant difference in A-I levels between normal and mild pre-eclamptic pregnancy at weeks 30, 35, 37, between normal and severe pre-eclamptic pregnancy at week 37. There were no differences in serum P-LAP between normal and mild pre-eclamptic pregnancy up to week 33, but thereafter the levels for the mild pre-eclampsia were significantly higher than for the normal pregnancy. The P-LAP activity for the severe pre-eclampsia reached its maximum level at week 31. Around this week, the levels for severe pre-eclampsia were significantly higher than in the normal pregnancy. After week 35, the activities decreased precipitously to week 40; the activities for severe pre-eclampsia in late pregnancy at weeks 39 and 40 were significantly lower than in normal pregnancy. The above data support the idea that P-LAP test is useful for prediction or diagnosis of pre-eclampsia.
AuthorsS Mizutani, H Akiyama, O Kurauchi, H Taira, O Narita, Y Tomoda
JournalArchives of gynecology (Arch Gynecol) Vol. 236 Issue 3 Pg. 165-72 ( 1985) ISSN: 0170-9925 [Print] Germany
PMID4015192 (Publication Type: Journal Article)
Chemical References
  • Angiotensins
  • Angiotensin I
  • Leucyl Aminopeptidase
Topics
  • Adult
  • Angiotensin I (blood)
  • Angiotensins (blood)
  • Female
  • Humans
  • Infant, Newborn
  • Leucyl Aminopeptidase (blood)
  • Placenta (enzymology)
  • Placental Function Tests
  • Pre-Eclampsia (blood, diagnosis, enzymology)
  • Pregnancy

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