CFU-C abnormalities and cytochemical defects in bone marrow of adult patients during remission of acute leukemia.

Abstract

Twenty-three adult patients in complete remission (CR) from acute leukemia were investigated for the steady-state bone marrow (BM) CFU-C concentration and the cytochemical findings of neutrophils and monocytes. There was considerable variation in CFU-C concentrations among patients. Patients with abnormality high or low values tended to relapse earlier. Repeated assays revealed constant CFU-C values in individual long-term cases of remission (4 cases). One case of M4 (myelomonocytic) and the case of M5b (monocytic) leukemia revealed a complete lack of nonspecific esterase activity in CR monocytes as well as initial leukemic promonocytes; they also showed abnormally high or low concentrations of CFU-C and relapsed early. This finding suggests that hematopoiesis in CR bone marrow occurs from abnormal stem cells common to initial, acute leukemic clones in such cases.

• Authors: T Matsuo, M Tomonaga, K Kuriyama, Y Yoshida, T Amenomori, H Nonaka, I Jinnai, M Ichimaru
• Journal: Leukemia research (Leuk Res) Vol. 9 Issue 5 Pg. 613-6 ( 1985) ISSN: 0145-2126 [Print] England
• PMID: 4010325 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carboxylic Ester Hydrolases
• butyrylesterase

Topics

• Acute Disease
• Aged
• Bone Marrow (pathology)
• Carboxylic Ester Hydrolases (metabolism)
• Colony-Forming Units Assay
• Female
• Hematopoietic Stem Cells (pathology)
• Histocytochemistry
• Humans
• Leukemia (enzymology, pathology)
• Male
• Middle Aged
• Monocytes (enzymology, pathology)
• Neutrophils (enzymology, pathology)
• Recurrence