Activity of flumequine against Escherichia coli: in vitro comparison with nalidixic and oxolinic acids.

Abstract

The in vitro activity of the new antibacterial agent, flumequine, against Escherichia coli was compared with those of oxolinic acid and nalidixic acid. As judged by turbidimetric criteria, flumequine was considerably more active than nalidixic acid and slightly less active than oxolinic acid against both nalidixic acid-susceptible and -resistant strains. Resistance to all three drugs could be easily induced in vitro. The comparative efficacy of flumequine, oxolinic acid, and nalidixic acid was also tested in an in vitro model of the treatment of bacterial cystitis. In this system, suppression of bacterial growth was obtained with markedly lower concentrations of flumequine and oxolinic acid than of nalidixic acid, but prevention of the emergence of bacterial populations that exhibited increased resistance to these compounds depended on the maintenance of adequate drug levels.

• Authors: D Greenwood
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 13 Issue 3 Pg. 479-83 (Mar 1978) ISSN: 0066-4804 [Print] United States
• PMID: 400825 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fluoroquinolones
• Quinolizines
• Nalidixic Acid
• Oxolinic Acid
• flumequine

Topics

• Chemical Phenomena
• Chemistry
• Drug Resistance, Microbial
• Escherichia coli (drug effects)
• Fluoroquinolones
• Microbial Sensitivity Tests
• Nalidixic Acid (pharmacology)
• Oxolinic Acid (pharmacology)
• Quinolizines (pharmacology)