Single-dose pharmacokinetic and pharmacodynamic comparison of polymer-matrix (Slow Trasicor) and Oros dosage forms of oxprenolol in healthy volunteers.

Oxprenolol was administered in single doses by mouth to healthy volunteers either in a polymer-matrix slow-release formulation (Slow Trasicor) or in osmotic drug-delivery systems (oxprenolol Oros). Plasma oxprenolol concentrations and heart rates after exercise were measured. Plasma concentrations of the drug were maximal at 3 h but negligible at 24 h after administration of Slow Trasicor. Following ingestion of the Oros systems measurable concentrations were maintained throughout 24 h. Significant reduction of exercise-induced tachycardia persisted for 24 h after administration of oxprenolol Oros. With Slow Trasicor heart rate responses had returned to baseline values by this time. The osmotic drug-delivery systems appear to sustain significant beta-adrenoceptor blockade for 24 h after a single oral dose.
AuthorsP N Bennett, J Bennett, I Bradbrook, J Francis, V A John, H Rogers, P Turner, S J Warrington
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 19 Suppl 2 Pg. 171S-175S ( 1985) ISSN: 0306-5251 [Print] ENGLAND
PMID4005119 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Oxprenolol
  • Adult
  • Delayed-Action Preparations
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Kinetics
  • Male
  • Oxprenolol (administration & dosage, metabolism, pharmacology)
  • Physical Exertion

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: