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Single-dose pharmacokinetic and pharmacodynamic comparison of polymer-matrix (Slow Trasicor) and Oros dosage forms of oxprenolol in healthy volunteers.

Abstract
Oxprenolol was administered in single doses by mouth to healthy volunteers either in a polymer-matrix slow-release formulation (Slow Trasicor) or in osmotic drug-delivery systems (oxprenolol Oros). Plasma oxprenolol concentrations and heart rates after exercise were measured. Plasma concentrations of the drug were maximal at 3 h but negligible at 24 h after administration of Slow Trasicor. Following ingestion of the Oros systems measurable concentrations were maintained throughout 24 h. Significant reduction of exercise-induced tachycardia persisted for 24 h after administration of oxprenolol Oros. With Slow Trasicor heart rate responses had returned to baseline values by this time. The osmotic drug-delivery systems appear to sustain significant beta-adrenoceptor blockade for 24 h after a single oral dose.
AuthorsP N Bennett, J Bennett, I Bradbrook, J Francis, V A John, H Rogers, P Turner, S J Warrington
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 19 Suppl 2 Pg. 171S-175S ( 1985) ISSN: 0306-5251 [Print] ENGLAND
PMID4005119 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Oxprenolol
Topics
  • Adult
  • Delayed-Action Preparations
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Kinetics
  • Male
  • Oxprenolol (administration & dosage, metabolism, pharmacology)
  • Physical Exertion

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