Topical steroids in anterior uveitis.

Abstract

The results are presented of a double-blind trial comparing the efficacy of betamethasone phosphate 0.1 per cent, clobetasone butyrate 0.1 per cent, and placebo in the treatment of acute unilateral non-granulomatous uveitis. The two steroids gave comparable results in improvement of the patients' symptoms, although betamethasone phosphate was significantly more effective than clobetasone butyrate in improving the ocular signs of uveitis. In comparing the placebo group of patients with those given topical steroids, the former group, though improving, appeared to lag behind by approximately 1 week. Four patients receiving placebo, however, had to be withdrawn because of worsening of the condition. Mild cases of anterior uveitis would probably resolve without using topical steroids.

• Authors: J A Dunne, J P Travers
• Journal: Transactions of the ophthalmological societies of the United Kingdom (Trans Ophthalmol Soc U K (1962)) Vol. 99 Issue 4 Pg. 481-4 ( 1979) ISSN: 0078-5334 [Print] England
• PMID: 400313 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Ophthalmic Solutions
• betamethasone sodium phosphate
• clobetasone butyrate
• Betamethasone
• Clobetasol

Topics

• Acute Disease
• Adult
• Aged
• Betamethasone (analogs & derivatives, therapeutic use)
• Clinical Trials as Topic
• Clobetasol (analogs & derivatives, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Random Allocation
• Uveitis, Anterior (drug therapy)