Increased serum antibody levels against cow's milk proteins in children with chronic liver disease.

Abstract

We measured IgG, IgM and IgA antibodies to cow's milk proteins: alpha-casein, alpha-lactalbumin, bovine serum albumin, beta-lactoglobulin-a and beta-lactoglobulin-b in the sera of 29 pediatric patients with liver disease. IgG antibodies to bovine serum albumin, beta-lactoglobulin-a and beta-lactoglobulin-b and IgA antibodies to alpha-casein were elevated in most of the patients compared to age-matched controls. We postulate that, in patients with liver disease either increased intestinal uptake resulting in increased humoral response, or decreased hepatic clearance of food antigens intensifying a humoral response to these foreign antigens, may occur.

• Authors: A Lerner, B H Park, T M Rossi, E Lebenthal
• Journal: Hepatology (Baltimore, Md.) (Hepatology) 1985 May-Jun Vol. 5 Issue 3 Pg. 488-91 ISSN: 0270-9139 [Print] United States
• PMID: 3997077 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antibodies
• Caseins
• Immunoglobulin A
• Immunoglobulin G
• Lactoglobulins
• Milk Proteins
• Lactalbumin

Topics

• Adolescent
• Adult
• Antibodies (analysis)
• Caseins (immunology)
• Child
• Child, Preschool
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Infant
• Lactalbumin (immunology)
• Lactoglobulins (immunology)
• Liver Diseases (immunology)
• Male
• Milk Proteins (immunology)