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Macrophage function in primary and secondary glomerulonephritis.

Abstract
The function of the mononuclear phagocyte system was assessed in vivo in 85 patients with primary and secondary glomerulonephritis, by measuring the clearance of IgG - sensitised 51Cr-labelled autologous erythrocytes. Eleven per cent of patients in clinical remission were found to have a delayed clearance, whereas impaired macrophage function was present in 62.5 per cent of the patients with major urinary abnormalities. Blockade of mononuclear phagocyte system, induced at least in part by unidentified factors, might have a role in development and perpetuation of glomerular injury.
AuthorsD Roccatello, R Coppo, G Martina, C Rollino, B Basolo, G Picciotto, F Bayle, P Bajardi, A Amoroso, D Cordonnier
JournalProceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress (Proc Eur Dial Transplant Assoc Eur Ren Assoc) Vol. 21 Pg. 661-5 ( 1985) England
PMID3991558 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antigen-Antibody Complex
  • HLA Antigens
  • Receptors, Fc
Topics
  • Adult
  • Aged
  • Antigen-Antibody Complex (analysis)
  • Female
  • Glomerulonephritis (immunology)
  • HLA Antigens
  • Humans
  • Macrophages (immunology)
  • Male
  • Middle Aged
  • Receptors, Fc

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