Treatment of acute bronchitis and pneumonia with cefaclor.

An open, non-comparative clinical trial of cefaclor in adults with acute exacerbations of chronic bronchitis (54 patients) or pneumonia (24 patients) is reported. The dosage of cefaclor used was either 250 mg or 500 mg taken orally three times daily. Clinical cure was obtained in 39 of 42 (93%) of patients on the lower dose and 32 of 33 (97%) on the higher dose. Side effects were minimal and the antibiotic was very well tolerated. Microbiological evaluation was possible in 32 of 75 (43%) of patients in whom potential pathogens were identified before treatment. Microbiological 'cure' was achieved in 17 of 32 (53%), the majority of whom had received the higher dose. The lack of correlation between the clinical and microbiological results cast further doubts on the value of the standard sputum culture methods in the diagnosis and management of lower respiratory tract infection. Cefaclor is useful in the management of acute lower respiratory tract infections by virtue of its excellent clinical efficacy and safety.
AuthorsK Mattson, O V Renkonen, L Laitinen, R Nikander-Hurme
JournalPostgraduate medical journal (Postgrad Med J) Vol. 55 Suppl 4 Pg. 59-61 ( 1979) ISSN: 0032-5473 [Print] ENGLAND
PMID398482 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Cefaclor
  • Cephalexin
  • Acute Disease
  • Bacteria (isolation & purification)
  • Bronchitis (drug therapy, microbiology)
  • Cefaclor (administration & dosage, therapeutic use)
  • Cephalexin (analogs & derivatives)
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Humans
  • Pneumonia (drug therapy, microbiology)
  • Sputum (microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: