[Immunohistochemical findings in intrathoracic tumors. VI. N-acetyl-beta-glucosaminidase].

Abstract

N-Acetyl-beta-Glucosaminidase (NAG) activity was investigated in 50 intrathoracic tumors with a histochemical method. Altogether, 22 of 50 (= 44%) different tumors showed enzyme activity in tumor tissue. The distribution of positive findings in bronchial carcinomas showed a marked difference between epidermoid carcinomas and adenoid carcinomas. Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. The fact that also non-differentiated solid adenocarcinomas, often in histological picture not to differentiate from large cell carcinomas or non-differentiated epidermoid carcinomas, exhibit NAG seems to be an useful aid in differential diagnosis between these tumor types.

• Authors: H Eckert
• Journal: Zeitschrift fur Erkrankungen der Atmungsorgane (Z Erkr Atmungsorgane) Vol. 164 Issue 1 Pg. 83-7 ( 1985) ISSN: 0303-657X [Print] Germany
• Vernacular Title: Immunhistochemische Befunde bei intrathorakalen Tumoren. VI. N-Azetyl-beta-Glukosaminidase.
• PMID: 3984403 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hexosaminidases
• Acetylglucosaminidase

Topics

• Acetylglucosaminidase (metabolism)
• Carcinoma, Bronchogenic (enzymology)
• Epithelium (enzymology)
• Hexosaminidases (metabolism)
• Humans
• Lung (enzymology)
• Lung Diseases (enzymology)
• Lung Neoplasms (enzymology)
• Pulmonary Fibrosis (enzymology)
• Sarcoidosis (enzymology)