HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Age-dependent lidocaine disposition in patients with acute myocardial infarction.

Abstract
To evaluate age-dependent changes in lidocaine disposition in patients with acute myocardial infarction, we measured plasma concentrations of lidocaine and its metabolites monoethylglycinexylidide and glycinexylidide after discontinuation of a maintenance lidocaine infusion. Plasma lidocaine clearance was calculated by dividing the lidocaine concentration at the end of the infusion into the maintenance infusion rate. Lidocaine clearance in 35 patients was related to body weight and was reduced by heart failure. Heart failure was more common in the elderly, occurring in 15 of 27 (56%) patients over 65 years old and seven of 29 (24%) patients under 65 years old. There was a reduction in lidocaine clearance with age due, in part, to lower body weight and a higher prevalence of heart failure in the elderly. Multilinear regression analysis showed that age and weight contributed to the prediction of lidocaine plasma clearance in patients with and without heart failure. Age was a particularly important predictor of lidocaine clearance in patients with heart failure. Adjustment of lidocaine maintenance doses based on age, weight, and heart failure may help control the frequency of lidocaine adverse reactions in the elderly.
AuthorsJ Cusson, S Nattel, C Matthews, M Talajic, S Lawand
JournalClinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 37 Issue 4 Pg. 381-6 (Apr 1985) ISSN: 0009-9236 [Print] UNITED STATES
PMID3978999 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • monoethylglycinexylidide
  • Lidocaine
  • glycinexylidide
Topics
  • Adult
  • Age Factors
  • Aged
  • Body Weight
  • Chromatography, High Pressure Liquid
  • Female
  • Heart Failure (chemically induced)
  • Humans
  • Infusions, Parenteral
  • Kinetics
  • Lidocaine (adverse effects, analogs & derivatives, analysis, blood, metabolism, therapeutic use)
  • Male
  • Middle Aged
  • Myocardial Infarction (drug therapy, metabolism)
  • Regression Analysis

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: