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Terminal deoxynucleotidyl transferase activity in childhood leukemia.

Abstract
The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.
AuthorsN Winick, P G Steinherz, D R Miller
JournalCancer (Cancer) Vol. 55 Issue 9 Pg. 1943-7 (May 01 1985) ISSN: 0008-543X [Print] United States
PMID3978575 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA Nucleotidyltransferases
  • DNA Nucleotidylexotransferase
Topics
  • Acute Disease
  • Adolescent
  • Bone Marrow (enzymology)
  • Child
  • Child, Preschool
  • DNA Nucleotidylexotransferase (metabolism)
  • DNA Nucleotidyltransferases (metabolism)
  • Female
  • Humans
  • Infant
  • Leukemia (enzymology)
  • Male
  • Prognosis
  • Time Factors

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