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Endothelial cell cytotoxicity in inflammatory vascular diseases--the possible role of oxidised lipoproteins.

Abstract
One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is unclear, but has been suggested to be a lipoprotein. Sera from patients with (1) systemic necrotising arteritis (polyarteritis nodosa, Wegener's granulomatosis, and necrotising arteritis associated with rheumatoid synovitis), (2) systemic or joint restricted rheumatoid disease, and (3) large vessel/giant cell arteritis have been examined for cytotoxicity to human cultured endothelial cells and azide-resistant ferroxidase-like activity (indicative of the oxidised lipoprotein content). Stored sera from patients with necrotising arteritis showed a significantly enhanced tendency to develop oxidised lipoprotein, which correlated closely with human endothelial cell cytotoxicity. Fresh sera also contained this factor, but to a lesser extent. It is argued that the cytotoxic factor detected in previous clinical studies is in part an in-vitro artefact, although its accelerated development in certain patient groups might suggest an excess of pro-oxidants that have developed in vivo.
AuthorsD R Blake, P Winyard, D G Scott, S Brailsford, A Blann, J Lunec
JournalAnnals of the rheumatic diseases (Ann Rheum Dis) Vol. 44 Issue 3 Pg. 176-82 (Mar 1985) ISSN: 0003-4967 [Print] England
PMID3977420 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Azides
  • Lipoproteins
Topics
  • Arteritis (blood, immunology)
  • Arthritis, Rheumatoid (blood, immunology)
  • Azides (pharmacology)
  • Cell Survival
  • Cells, Cultured
  • Cytotoxicity, Immunologic
  • Endothelium (cytology, immunology)
  • Humans
  • Lipoproteins (blood, immunology)
  • Oxidation-Reduction

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