Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease.

Abstract

Splenic atrophy or evidence of hyposplenism occurs in as many as one third of all patients with S-C hemoglobinopathy. Yet there are few reports in the literature of clinically apparent splenic infarction in this disease. We describe four instances of acute splenic infarction in three patients with hemoglobin S-C disease which illustrate a wide spectrum of clinical manifestations and severity. Of particular interest were the observations of coincident occurrences of splenic sequestration and functional hyposplenism with splenic infarction, suggesting a close pathophysiological relationship among these syndromes.

• Authors: D A Sears, M M Udden
• Journal: American journal of hematology (Am J Hematol) Vol. 18 Issue 3 Pg. 261-8 (Mar 1985) ISSN: 0361-8609 [Print] United States
• PMID: 3976642 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Adult
• Anemia, Sickle Cell (complications)
• Atrophy
• Female
• Hemoglobin SC Disease (complications, physiopathology)
• Humans
• Male
• Radionuclide Imaging
• Spleen (diagnostic imaging, pathology, physiopathology)
• Splenic Infarction (etiology)
• Splenomegaly (etiology)