Effects of plasma treatment with purified protein A and Staphylococcus aureus Cowan I on spontaneous animal neoplasms.

Abstract

Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semi-automatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral "blocking" factors.

• Authors: J S Klausner, W J Miller, T D O'Brien, R F Branda
• Journal: Cancer research (Cancer Res) Vol. 45 Issue 3 Pg. 1263-9 (Mar 1985) ISSN: 0008-5472 [Print] United States
• PMID: 3971372 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunoglobulin G
• Staphylococcal Protein A
• Sepharose

Topics

• Animals
• Cat Diseases (therapy)
• Cats
• Dog Diseases (therapy)
• Dogs
• Female
• Immunoglobulin G (analysis)
• Male
• Neoplasms (therapy, veterinary)
• Perfusion (methods)
• Plasma
• Sepharose (administration & dosage)
• Staphylococcal Protein A (administration & dosage)
• Staphylococcus aureus