Platelet and fibrinogen kinetics in healthy and African swine fever-affected swine: [75Se]selenomethionine-labeling study.

Abstract

Platelet and fibrinogen survival times were determined in healthy pigs and in pigs infected with African swine fever (ASF) virus. Cohort labeling with [75Se]selenomethionine was performed. The platelet survival time in healthy pigs was 5.3 +/- 0.7 days, and the fibrinogen survival time was 6.7 +/- 0.8 days. Early deaths and profound thrombocytopenia prevented calculation of accurate platelet and fibrinogen survival times in ASF virus-infected animals. The ASF virus-infected pigs died of extensive hemorrhage and effusions while thrombocytopenic; however, there was normal thrombocytopoiesis during infection, as measured by incorporation of the radionuclide into platelets. There was a slight decrease in plasma fibrinogen concentration when the platelet count decreased. A dysfunctional fibrinogen was present late in the infection.

• Authors: J F Edwards, W J Dodds
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 46 Issue 1 Pg. 181-4 (Jan 1985) ISSN: 0002-9645 [Print] United States
• PMID: 3970425 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fibrinogen
• Selenomethionine
• Selenium

Topics

• African Swine Fever (blood)
• Animals
• Blood Platelets (cytology, physiology)
• Cell Survival
• Fibrinogen (metabolism)
• Hematopoiesis
• Platelet Count (veterinary)
• Selenium
• Selenomethionine
• Swine (blood)