Isosorbide dinitrate sublingual therapy for inferior myocardial infarction: randomized trial to assess infarct size limitation.

Abstract

To assess the potential of isosorbide dinitrate sublingual therapy for limiting myocardial infarct size, 41 patients with inferior acute myocardial infarction (AMI) were studied. Twenty patients were randomly assigned to the control group and 21 to the treatment group. Patients in the treatment group received 10 mg of isosorbide dinitrate every 2 hours for 72 hours. To estimate infarct size, QRS scoring, peak creatine kinase (CK) serum levels and CK curves were used. There were no significant differences between the 2 groups in maximal or cumulative activity of CK or QRS score (percent of left ventricle infarcted: 16% in the control group, 17% in the treatment group). In both groups the QRS score increased significantly by 13 hours after AMI, and the increase was highly significant by 19 to 23 hours. Thus, sublingual isosorbide dinitrate at the dosage given did not reduce infarct size in patients with inferior AMI.

• Authors: P Pabón Osuna, L M García Moreno, A Arribas Jimenez, A Sala Sánchez-Castillo, C Martín Luengo, J Sánchez Hernández, L Castaño Bazo, M Cascón Bueno, M Diego Dominguez, C Ledesma García
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 55 Issue 4 Pg. 330-4 (Feb 01 1985) ISSN: 0002-9149 [Print] United States
• PMID: 3969867 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Creatine Kinase
• Isosorbide Dinitrate

Topics

• Administration, Oral
• Creatine Kinase (blood)
• Electrocardiography
• Hemodynamics (drug effects)
• Humans
• Isosorbide Dinitrate (therapeutic use)
• Myocardial Infarction (drug therapy, enzymology, physiopathology)
• Prospective Studies
• Random Allocation