Abstract |
The Central Pennsylvania Oncology Group conducted a phase II study of mitolactol in advanced metastatic melanoma to determine the overall survival rate and duration of response to this agent. The starting dose was 100 mg/m2/day orally. If no hematologic toxicity was noted on weekly blood cell counts, the dose was increased to 130 mg/m2/day on Day 35, and, if still tolerated, to 160 mg/m2/day on Day 70. Six of 25 evaluable patients (24%) had objective partial response. The median duration of response was 20 weeks, with a range of 10-66 weeks. Six of 25 patients (24%) had stable measurable disease, with a median duration of 9 weeks. The median survival from date of entry in this study was 21 weeks in responding or stable patients compared to 7 weeks in nonresponders. Hematologic toxicity was the dose-limiting factor. This study shows that mitolactol has moderate activity against advanced melanoma, and the drug deserves further study in combination with nonmyelotoxic drugs.
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Authors | M A Simmonds, A Lipton, H A Harvey, N Ellison, D S White |
Journal | Cancer treatment reports
(Cancer Treat Rep)
Vol. 69
Issue 1
Pg. 65-7
(Jan 1985)
ISSN: 0361-5960 [Print] United States |
PMID | 3967260
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Bone Marrow
(drug effects)
- Drug Evaluation
- Female
- Hemoglobins
(analysis)
- Humans
- Leukocyte Count
- Male
- Melanoma
(drug therapy, mortality, pathology)
- Middle Aged
- Mitolactol
(adverse effects, therapeutic use)
- Neoplasm Metastasis
- Platelet Count
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