HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

New metabolites of Fusarium martii related to dihydrofusarubin.

Abstract
Six strains of Fusarium martii produced fusarubin and dihydrofusarubins A and B. Further examination of strains, T-77 and T-127, showed that four additional metabolites were produced. By 1H and 13C NMR spectral analyses, these additional metabolites have been identified as 3-O-methyl and 3-O-ethyl ethers of fusarubin and dihydrofusarubin A. The methyl ethers are new compounds and showed moderate cytostatic activity against mouse leukemia L1210 culture cells as well as moderate antibiotic activity against leukemia L1210 culture cells as well as moderate antibiotic activity against Gram-positive bacteria and fungi. 3-O-Methyl and 3-O-ethyl ethers of dihydrofusarubin A were converted non-enzymically to the respective ethers of fusarubin under alkaline conditions. Since in addition, only dihydrofusarubin derivatives were formed when an acidic pH was maintained in the culture, it can be concluded that only these are true metabolites of Fusarium martii.
AuthorsI Kurobane, N Zaita, A Fukuda
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 39 Issue 2 Pg. 205-14 (Feb 1986) ISSN: 0021-8820 [Print] England
PMID3957787 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Naphthols
  • 4,10-dihydrofusarubin
Topics
  • Animals
  • Antibiotics, Antineoplastic (biosynthesis, pharmacology)
  • Chemical Phenomena
  • Chemistry
  • Fusarium (metabolism)
  • Hydrogen-Ion Concentration
  • Leukemia L1210 (drug therapy)
  • Magnetic Resonance Spectroscopy
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Naphthols (biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: