Experience with Althesin in the management of persistently raised ICP following severe head injury.

Abstract

Of 243 patients who underwent intracranial pressure (ICP) monitoring after severe head injury, 42 (17%) were found to have severe persistently raised ICP, in spite of hyperventilation, mannitol, and surgical decompression. Althesin was infused to reduce ICP in these patients. This agent was shown to be effective and safe in reducing ICP, and a significant improvement in cerebral perfusion pressure was demonstrated. In this respect, Althesin may be more effective than barbiturates. However, no improvement in patient outcome was demonstrated in this series.

• Authors: R Bullock, J R van Dellen, D Campbell, I Osborn, S G Reinach
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 64 Issue 3 Pg. 414-9 (Mar 1986) ISSN: 0022-3085 [Print] United States
• PMID: 3950721 (Publication Type: Journal Article)

Chemical References

• Alfaxalone Alfadolone Mixture

Topics

• Adolescent
• Adult
• Alfaxalone Alfadolone Mixture (therapeutic use)
• Brain Injuries (drug therapy)
• Cerebrovascular Circulation (drug effects)
• Child
• Child, Preschool
• Humans
• Infant
• Intracranial Pressure (drug effects)
• Middle Aged