Abstract |
Six cases of Swyer's syndrome (46, XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in the first sibling, who presented with a gonadoblastoma and underwent a gonadectomy before the H-Y assays, was intermediate, and did not show any significant variation for 21 months. H-Y antigen level in the second sibling showed an increase in the male range, presumably due to the presence of gonadoblastomas. After resection of the tumors, H-Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46, XY pure gonadal dysgenesis.
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Authors | V Amice, J Amice, J P Bercovici, D Riviere, M J Corolleur |
Journal | Cancer
(Cancer)
Vol. 57
Issue 7
Pg. 1313-7
(Apr 01 1986)
ISSN: 0008-543X [Print] United States |
PMID | 3948114
(Publication Type: Case Reports, Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Dysgerminoma
(complications, immunology)
- Female
- Genital Neoplasms, Female
(complications, immunology)
- Gonadal Dysgenesis
(immunology)
- Gonadal Dysgenesis, 46,XY
(complications, immunology)
- H-Y Antigen
(analysis)
- Humans
- Karyotyping
- Leukocytes
(immunology)
- Male
- Virilism
(complications)
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