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Reactivity of mouse monoclonal antibody M2590 against B16 melanoma cells with chemically synthesized GM3 ganglioside.

Abstract
A mouse (C57BL/6) monoclonal antibody M2590, which is established against syngeneic melanoma B16 cells, reacted with chemically synthesized GM3. NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1' ceramide (24:0/d 18:1), but not with its stereoisomer, NeuAc beta 2-3Gal beta 1-4Glc beta 1-1' ceramide (24:0/d 18:1).
AuthorsY Hirabayashi, M Sugimoto, T Ogawa, M Matsumoto, M Tagawa, M Taniguchi
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 875 Issue 1 Pg. 126-8 (Jan 03 1986) ISSN: 0006-3002 [Print] Netherlands
PMID3940532 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antigen-Antibody Complex
  • G(M1) Ganglioside
Topics
  • Animals
  • Antibodies, Monoclonal (immunology)
  • Antigen-Antibody Complex
  • Cell Line
  • G(M1) Ganglioside (immunology)
  • Kinetics
  • Melanoma (immunology)
  • Mice
  • Mice, Inbred C57BL

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