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Good diabetic control early in pregnancy and favorable fetal outcome.

Abstract
This study of 74 diabetic pregnant women shows that tight maternal blood glucose control before the 32nd week of gestation significantly reduces the incidence of fetal macrosomia (11%) when compared with that of patients with fair to poor control before the 32nd week of gestation (44%, P less than .05) or with those whose good diabetic control was not achieved until after the 32nd week of gestation (34%, P less than .05). The macrosomic infant produced by a diabetic mother is associated frequently with an elevated amniotic fluid C-peptide level, which shows the evidence of intrauterine fetal hyperinsulinism. The use of tight diabetic control early in pregnancy to reduce the risk of fetal macrosomia and/or neonatal complications is of clinical importance in the management of diabetes in pregnancy.
AuthorsC C Lin, J River, P River, P M Blix, A H Moawad
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 67 Issue 1 Pg. 51-6 (Jan 1986) ISSN: 0029-7844 [Print] United States
PMID3940338 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Blood Glucose
  • C-Peptide
Topics
  • Amniotic Fluid (metabolism)
  • Birth Weight
  • Blood Glucose (metabolism)
  • C-Peptide (metabolism)
  • Diabetes Mellitus, Type 1 (metabolism, prevention & control)
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Hypoglycemia (prevention & control)
  • Infant, Newborn
  • Infant, Small for Gestational Age
  • Jaundice, Neonatal (prevention & control)
  • Longitudinal Studies
  • Pregnancy
  • Pregnancy in Diabetics (metabolism, prevention & control)
  • Time Factors

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