Abstract |
This study of 74 diabetic pregnant women shows that tight maternal blood glucose control before the 32nd week of gestation significantly reduces the incidence of fetal macrosomia (11%) when compared with that of patients with fair to poor control before the 32nd week of gestation (44%, P less than .05) or with those whose good diabetic control was not achieved until after the 32nd week of gestation (34%, P less than .05). The macrosomic infant produced by a diabetic mother is associated frequently with an elevated amniotic fluid C-peptide level, which shows the evidence of intrauterine fetal hyperinsulinism. The use of tight diabetic control early in pregnancy to reduce the risk of fetal macrosomia and/or neonatal complications is of clinical importance in the management of diabetes in pregnancy.
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Authors | C C Lin, J River, P River, P M Blix, A H Moawad |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 67
Issue 1
Pg. 51-6
(Jan 1986)
ISSN: 0029-7844 [Print] United States |
PMID | 3940338
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Amniotic Fluid
(metabolism)
- Birth Weight
- Blood Glucose
(metabolism)
- C-Peptide
(metabolism)
- Diabetes Mellitus, Type 1
(metabolism, prevention & control)
- Female
- Follow-Up Studies
- Gestational Age
- Humans
- Hypoglycemia
(prevention & control)
- Infant, Newborn
- Infant, Small for Gestational Age
- Jaundice, Neonatal
(prevention & control)
- Longitudinal Studies
- Pregnancy
- Pregnancy in Diabetics
(metabolism, prevention & control)
- Time Factors
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