Abstract |
The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormone replacement therapy discontinued for 30 days. They were first treated with increasing L-T4 (0.1, 0.2 and 0.4 mg daily) followed by L-T3 (0.05 and 0.2 mg daily) after stopping thyroid medication for another month. Ten normal subjects were treated identically. In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses. In congenitally hypothyroid patients receiving 0.2 mg L-T4 daily, the mean peak TSH after TRH was 24 +/- 17 microU/ml, whereas in patients with an ectopic thyroid or adult-onset hypothyroidism the peak TSH was significantly less at 5.9 +/- 8.8 and 5.5 +/- 5.7 microU/ml, respectively. Only at the highest doses of L-T4 (0.4 mg/day) or L-T3 (0.2 mg/day) was the TSH response to TRH suppressed in the congenitally hypothyroid group. The alpha and TSH-beta subunit levels followed those of TSH.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | H Cavaliere, G A Medeiros-Neto, W Rosner, I A Kourides |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 8
Issue 6
Pg. 527-32
(Dec 1985)
ISSN: 0391-4097 [Print] Italy |
PMID | 3938790
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Sex Hormone-Binding Globulin
- Thyroid Hormones
- Triglycerides
- Triiodothyronine
- Thyrotropin-Releasing Hormone
- Thyrotropin
- Cholesterol
- Thyroxine
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Topics |
- Adolescent
- Adult
- Child
- Cholesterol
(blood)
- Congenital Hypothyroidism
- Drug Resistance
- Female
- Humans
- Hypothyroidism
(blood, drug therapy)
- Male
- Pituitary Gland
(drug effects)
- Sex Hormone-Binding Globulin
(metabolism)
- Thyroid Hormones
(therapeutic use)
- Thyrotropin
(blood)
- Thyrotropin-Releasing Hormone
- Thyroxine
(therapeutic use)
- Triglycerides
(blood)
- Triiodothyronine
(therapeutic use)
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