Central cholinergic-dopaminergic interaction in carbaryl-induced tremor.

Abstract

Acute administration of the anticholinesterase agent carbaryl to rats produced a dose-dependent increase of tremors. The carbaryl-induced tremor was significantly reduced by prior treatment of the rats with either atropine or L-DOPA and was exacerbated by haloperidol. These results suggest the possible involvement of a central cholinergic-dopaminergic interaction in the carbaryl-induced tremor.

• Authors: S K Ray, M K Poddar
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 119 Issue 3 Pg. 251-3 (Dec 17 1985) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3937737 (Publication Type: Journal Article)

Chemical References

• Receptors, Cholinergic
• Receptors, Dopamine
• Levodopa
• Atropine
• Haloperidol
• Carbidopa
• Carbaryl

Topics

• Animals
• Atropine (pharmacology)
• Carbaryl (antagonists & inhibitors, pharmacology)
• Carbidopa (pharmacology)
• Dose-Response Relationship, Drug
• Drug Synergism
• Haloperidol (pharmacology)
• Levodopa (pharmacology)
• Male
• Rats
• Receptors, Cholinergic (physiology)
• Receptors, Dopamine (physiology)
• Tremor (chemically induced, metabolism)