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Inhibitory effect of tumor necrosis serum on the metastasis of B-16 mouse melanoma cells.

Abstract
The inhibitory effect of tumor necrosis serum (TNS) on the artificial metastasis of B-16 melanoma cells and the spontaneous metastasis of Lewis lung carcinoma cells was investigated. The results obtained were as follows: 1) When tumor necrosis serum (TNS) was administered either 20 min or 2 days after injection of B-16 melanoma cells, a very strong inhibitory effect (99%) relative to the control was noted. 2) TNS showed a 60% inhibitory effect on spontaneous metastasis, and the weight of the original tumor regressed by 60%. 3) No histological changes in normal tissues were observed microscopically following TNS injection. The above results confirm that TNS is extremely effective in preventing metastasis.
AuthorsN Watanabe, Y Niitsu, H Sone, H Neda, N Yamauchi, I Urushizaki
JournalJapanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 76 Issue 10 Pg. 989-94 (Oct 1985) ISSN: 0910-5050 [Print] Japan
PMID3935629 (Publication Type: Journal Article)
Chemical References
  • Glycoproteins
  • Tumor Necrosis Factor-alpha
Topics
  • Animals
  • Cell Line
  • Glycoproteins (pharmacology)
  • Lung Neoplasms (pathology)
  • Melanoma (pathology)
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Metastasis
  • Tumor Necrosis Factor-alpha

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