Abstract |
The inhibitory effect of tumor necrosis serum ( TNS) on the artificial metastasis of B-16 melanoma cells and the spontaneous metastasis of Lewis lung carcinoma cells was investigated. The results obtained were as follows: 1) When tumor necrosis serum ( TNS) was administered either 20 min or 2 days after injection of B-16 melanoma cells, a very strong inhibitory effect (99%) relative to the control was noted. 2) TNS showed a 60% inhibitory effect on spontaneous metastasis, and the weight of the original tumor regressed by 60%. 3) No histological changes in normal tissues were observed microscopically following TNS injection. The above results confirm that TNS is extremely effective in preventing metastasis.
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Authors | N Watanabe, Y Niitsu, H Sone, H Neda, N Yamauchi, I Urushizaki |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 76
Issue 10
Pg. 989-94
(Oct 1985)
ISSN: 0910-5050 [Print] Japan |
PMID | 3935629
(Publication Type: Journal Article)
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Chemical References |
- Glycoproteins
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Cell Line
- Glycoproteins
(pharmacology)
- Lung Neoplasms
(pathology)
- Melanoma
(pathology)
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis
- Tumor Necrosis Factor-alpha
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