Neurology and the lupus anticoagulant.

Abstract

The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system. Thus far cerebral thrombosis, spinal thrombosis, chorea and Guillain-Barré syndrome have been described in association with the lupus anticoagulant. Although the lupus anticoagulant is an uncommon cause of neurological disease, it must be considered, especially in a setting of a prolongation of the common pathway of coagulation, thrombosis and other autoimmune phenomena.

• Authors: H Englert, G Derue, G R Hughes
• Journal: European neurology (Eur Neurol) Vol. 24 Issue 6 Pg. 422-5 ( 1985) ISSN: 0014-3022 [Print] Switzerland
• PMID: 3933980 (Publication Type: Journal Article)

Chemical References

• Blood Coagulation Factors
• Lupus Coagulation Inhibitor

Topics

• Blood Coagulation
• Blood Coagulation Factors (analysis, antagonists & inhibitors, immunology)
• Humans
• Lupus Coagulation Inhibitor
• Thrombocytopenia (immunology)
• Thrombosis (immunology)