Evidence that D-1 dopamine receptors contribute to the supersensitive behavioral responses induced by L-dihydroxyphenylalanine in rats treated neonatally with 6-hydroxydopamine.

Abstract

The present investigation supports the hypothesis that functionally supersensitive D-1 dopamine receptors are involved in the self-mutilation behavior (SMB) induced by L-dihydroxyphenylalanine (L-dopa) in rats treated neonatally with 6-hydroxydopamine (6-OHDA). This conclusion is based upon 1) the antagonism of this behavior by SCH-23390, a D-1 antagonist; 2) induction of SMB in neonatal-6-OHDA-treated rats by the D-1 agonist, SKF-38393; 3) the high correlation of the supersensitive locomotor responses to the D-1 agonist with the occurrence of L-dopa-induced SMB; and 4) the inability of the D-2 agonist, LY-171555, to induce SMB in rats treated neonatally with 6-OHDA. The specificity of SCH-23390 and SKF-38393 for the D-1 dopamine receptor was supported by the absence of action of SCH-23390 against locomotor activities induced by LY-171555 and its blockade of SKF-38393-induced locomotion in 6-OHDA-treated rats. Behavioral responses to D-1 and D-2 agonists did not show the same profile in adult and neonatally 6-OHDA-treated rats, providing further support for the view that the age at which dopaminergic neurons are destroyed has differing effects on motor output. Many of the behaviors observed when the D-2 dopamine receptor was activated by LY-171555 were apparent after SKF-38393 in neonatally 6-OHDA-treated rats. Similar behavioral responses to the D-1 and D-2 agonists were also observed in adult 6-OHDA-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: G R Breese, A Baumeister, T C Napier, G D Frye, R A Mueller
• Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 235 Issue 2 Pg. 287-95 (Nov 1985) ISSN: 0022-3565 [Print] United States
• PMID: 3932640 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzazepines
• Ergolines
• Hydroxydopamines
• Receptors, Dopamine
• Quinpirole
• Levodopa
• Dihydroxyphenylalanine
• 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
• Oxidopamine
• Flupenthixol
• Haloperidol

Topics

• 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
• Analysis of Variance
• Animals
• Animals, Newborn
• Behavior, Animal (drug effects)
• Benzazepines (pharmacology)
• Dihydroxyphenylalanine (pharmacology)
• Drug Interactions
• Ergolines (pharmacology)
• Female
• Flupenthixol (pharmacology)
• Haloperidol (pharmacology)
• Hydroxydopamines (pharmacology)
• Levodopa (pharmacology)
• Male
• Motor Activity (drug effects)
• Oxidopamine
• Pregnancy
• Quinpirole
• Rats
• Receptors, Dopamine (metabolism)
• Self Mutilation (chemically induced)
• Stereotyped Behavior (drug effects)