Efficacy of long-acting oxytetracycline alone or combined with streptomycin in the treatment of bovine brucellosis.

Abstract

Twenty-nine Brucella abortus culture-positive cows were treated with a long-acting oxytetracycline (20 mg/kg of body weight, IM) alone or combined with streptomycin (25 mg/kg, IM or IV) or were re-treated with the same product. There appeared to be a synergism by the 2 drugs. Of 21 courses of treatment with the combined antibiotics, 14 (67%) were considered successful. Only 3 of 14 (21%) were successful using oxytetracycline alone. The period from onset of therapy to cessation of shedding in udder secretions was variable. Four cows that ceased shedding were culture-positive in tissues taken at slaughter. The titers on tube agglutination and complement-fixation tests were of limited value in short-term evaluations of therapeutic regimens.

• Authors: P Nicoletti, F W Milward, E Hoffmann, L Altvater
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 187 Issue 5 Pg. 493-5 (Sep 01 1985) ISSN: 0003-1488 [Print] United States
• PMID: 3932272 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Oxytetracycline
• Streptomycin

Topics

• Agglutination Tests (veterinary)
• Animals
• Brucella abortus (drug effects)
• Brucellosis, Bovine (drug therapy)
• Cattle
• Complement Fixation Tests (veterinary)
• Drug Synergism
• Drug Therapy, Combination
• Female
• Oxytetracycline (administration & dosage, therapeutic use)
• Pregnancy
• Streptomycin (administration & dosage, therapeutic use)
• Time Factors