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Prolactin and thyrotropin response to thyrotropin-releasing-hormone in adolescent females with insulin-treated diabetes mellitus.

Abstract
Prolactin and thyrotropin response to TRH and basal gonadotropins levels in blood were investigated in insulin-treated adolescent females with regular menstruation cycles (Group I) and menstruation disturbances (Group II) compared with control, healthy girls. No significant differences were found in TSH secretion after TRH administration and basal LH, FSH levels between the observed groups. Blood basal PRL levels were significantly lower in young females in Group II, and a highly increased mobilization of PRL secretion (delta % PRL)--masked hyperprolactinaemia--in all of the groups of diabetic girls was revealed. Cytological examination of vaginal smears confirmed hypoestrogenic status of girls from Group II compared with Group I and the control group.
AuthorsJ M Komorowski, A Komorowska, H Dziatkowiak, I Owczarczyk, M Zawodniak
JournalExperimental and clinical endocrinology (Exp Clin Endocrinol) Vol. 85 Issue 3 Pg. 326-30 (Jun 1985) ISSN: 0232-7384 [Print] Germany
PMID3930271 (Publication Type: Journal Article)
Chemical References
  • Estrogens
  • Thyrotropin-Releasing Hormone
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Thyrotropin
Topics
  • Adolescent
  • Adult
  • Diabetes Mellitus, Type 1 (complications, physiopathology)
  • Estrogens (deficiency)
  • Female
  • Follicle Stimulating Hormone (blood)
  • Humans
  • Luteinizing Hormone (blood)
  • Menstruation Disturbances (complications, diagnosis, physiopathology)
  • Prolactin (metabolism)
  • Thyrotropin (metabolism)
  • Thyrotropin-Releasing Hormone
  • Vaginal Smears

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