The biological role of thromboxane A2 in the process of hemostasis and thrombosis; pharmacology and perspectives of therapeutical use of thromboxane synthetase inhibitors and receptor PGH2/TXA2 antagonists.

Abstract

The biological role of thromboxane A2 in the process of hemostasis and thrombosis; pharmacology and perspectives of the therapeutical use of thromboxane synthetase inhibitors and receptor PGH2/TXA2 antagonists. Acta physiol. pol., 1985, 36 (3): 153-164. The biology of thromboxane A2 and pharmacology of drugs that selectively inhibit generation and action of this eicosanoid are reviewed. Author's opinion on therapeutical perspectives for thromboxane synthetase inhibitors and receptor PGH2/TXA2 antagonists is also presented.

• Authors: M Radomski
• Journal: Acta physiologica Polonica (Acta Physiol Pol) 1985 May-Jun Vol. 36 Issue 3 Pg. 153-64 ISSN: 0044-6033 [Print] Poland
• PMID: 3915630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Prostaglandins
• Thromboxane A2
• Thromboxane-A Synthase
• Aspirin

Topics

• Aspirin (therapeutic use)
• Hemostasis
• Humans
• Muscle Contraction (drug effects)
• Platelet Aggregation (drug effects)
• Prostaglandins (pharmacology)
• Thrombosis (blood, drug therapy, prevention & control)
• Thromboxane A2 (blood)
• Thromboxane-A Synthase (antagonists & inhibitors)