Abstract |
Ninety-two outpatients with depressive disorders which met Research Diagnostic Criteria were treated either with mianserin or placebo in a 6-week controlled trial. Twenty-four of 42 (57%) mianserin-treated patients were rated responders to mianserin treatment while 15 of 50 (30%) were rated responders to placebo treatment (chi 2 = 6.89, p less than 0.01). This rate of drug response was comparable to that achieved with a tricyclic antidepressant in a similar study done in our clinic, supporting the use of mianserin in mildly depressed outpatients.
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Authors | P J McGrath, J G Rabkin, J W Stewart, W Harrison, F M Quitkin, J Markowitz |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 14
Issue 3
Pg. 128-32
( 1985)
ISSN: 0302-282X [Print] Switzerland |
PMID | 3913875
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Clinical Trials as Topic
- Depressive Disorder
(drug therapy)
- Dibenzazepines
(therapeutic use)
- Dizziness
(chemically induced)
- Female
- Headache
(chemically induced)
- Humans
- Hyperphagia
(chemically induced)
- Male
- Mianserin
(adverse effects, therapeutic use)
- Middle Aged
- Sleep Wake Disorders
(chemically induced)
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