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Placebo-controlled study of mianserin in depressed outpatients.

Abstract
Ninety-two outpatients with depressive disorders which met Research Diagnostic Criteria were treated either with mianserin or placebo in a 6-week controlled trial. Twenty-four of 42 (57%) mianserin-treated patients were rated responders to mianserin treatment while 15 of 50 (30%) were rated responders to placebo treatment (chi 2 = 6.89, p less than 0.01). This rate of drug response was comparable to that achieved with a tricyclic antidepressant in a similar study done in our clinic, supporting the use of mianserin in mildly depressed outpatients.
AuthorsP J McGrath, J G Rabkin, J W Stewart, W Harrison, F M Quitkin, J Markowitz
JournalNeuropsychobiology (Neuropsychobiology) Vol. 14 Issue 3 Pg. 128-32 ( 1985) ISSN: 0302-282X [Print] Switzerland
PMID3913875 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Dibenzazepines
  • Mianserin
Topics
  • Adolescent
  • Adult
  • Aged
  • Clinical Trials as Topic
  • Depressive Disorder (drug therapy)
  • Dibenzazepines (therapeutic use)
  • Dizziness (chemically induced)
  • Female
  • Headache (chemically induced)
  • Humans
  • Hyperphagia (chemically induced)
  • Male
  • Mianserin (adverse effects, therapeutic use)
  • Middle Aged
  • Sleep Wake Disorders (chemically induced)

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