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Treatment outcome validation of DSM-III depressive subtypes. Clinical usefulness in outpatients with mild to moderate depression.

Abstract
An algorithm for transcribing Research Diagnostic Criteria diagnoses for depressive disorders to similar categories in the DSM-III was applied to 103 depressed outpatients previously diagnosed by Research Diagnostic Criteria. All had Hamilton Depression Rating Scale scores of 18 or less. Among 64 patients completing a six-week, double-blind study comparing desipramine hydrochloride with placebo, desipramine was significantly more effective than placebo in patients with DSM-III major depression but not in those with dysthymic disorder. Among patients with major depression, a significant drug-placebo response difference was demonstrated even in those without melancholia. These findings support the clinical usefulness of the DSM-III in the treatment of depressed outpatients. Independent of DSM-III diagnosis, however, evidence of panic attacks seemed to identify patients who benefited from desipramine therapy. This suggests that the DSM-III hierarchy, which excludes consideration of panic in patients with major depression, may require revision.
AuthorsJ W Stewart, P J McGrath, M R Liebowitz, W Harrison, F Quitkin, J G Rabkin
JournalArchives of general psychiatry (Arch Gen Psychiatry) Vol. 42 Issue 12 Pg. 1148-53 (Dec 1985) ISSN: 0003-990X [Print] United States
PMID3907579 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Desipramine
Topics
  • Anxiety Disorders (drug therapy)
  • Bipolar Disorder (drug therapy)
  • Clinical Trials as Topic
  • Depressive Disorder (classification, diagnosis, drug therapy)
  • Desipramine (therapeutic use)
  • Double-Blind Method
  • Humans
  • Panic
  • Psychiatric Status Rating Scales
  • Random Allocation

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