[Dynamic evaluation of the renin-angiotensin system with captopril in screening for renovascular hypertension].

Abstract

In 69 hypertensive with suspected renovascular hypertension the response of plasma renin and angiotensin I to a single oral dose of Captopril (Captopril test) was determined. In 15 of the 16 patients found to have renal artery stenosis at angiography and cured by either revascularization or nephrectomy, Captopril stimulated both plasma renin activity and plasma angiotensin I to a far greater extent than in the majority of the 53 classified as essential hypertensives. False positives were limited to 8. Sensitivity and specificity were 94% and 85%, respectively. In the same series sequential renal angiophotoscan showed 100% sensitivity but a lower specificity (75%). In comparison, both the sensitivity and the specificity of rapid-sequence intravenous pielography, isotopic renogram and recumbent plasma renin activity were far less satisfactory. It is concluded that this simple, safe and economical test should be preferred to the other diagnostic procedures in the screening of renovascular hypertension. Its use in combination with renal angiophotoscan improves diagnostic reliability.

• Authors: G Rossi, A Semplicini, A C Pessina, F Perissinotto, R De Toni, G Feltrin, M G Mozzato, C Dal Palù
• Journal: Giornale italiano di cardiologia (G Ital Cardiol) Vol. 15 Issue 5 Pg. 472-7 (May 1985) ISSN: 0046-5968 [Print] Italy
• Vernacular Title: La valutazione dinamica del sistema renina-angiotensina con il captopril nello screening dell'ipertensione renovascolare.
• PMID: 3902548 (Publication Type: Journal Article)

Chemical References

• Angiotensin I
• Captopril
• Renin

Topics

• Adult
• Aged
• Angiotensin I (blood)
• Captopril
• Female
• Humans
• Hypertension, Renovascular (diagnosis)
• Male
• Middle Aged
• Nephrectomy
• Radiography
• Renal Artery (diagnostic imaging)
• Renin (blood)
• Renin-Angiotensin System (drug effects)