Cytolytic action of 60-F derived from live hemolytic streptococci against Ehrlich carcinoma cells.

Abstract

The effect of 60-F, a fraction obtained by 0.5 approximately 0.6 saturation of ammonium sulfate of streptomycin-pretreated cell-free extract from live hemolytic streptococci (avirulent Su strain), on release of 51Cr from the 51Cr-labeled Ehrlich ascites carcinoma cells was studied with following results: a) 60-F was found to be highly effective in releasing 51Cr from 51Cr-labeled Ehrlich ascites carcinoma cells. b) Additionally, destructive picutres of the tumor cells contacted with 60-F in vitro was observed by phase-contrast microscopic examination. c) Indication was that the 51Cr-releasing assay method is also useful for the study of the direct cytolytic effect of 60-F.

• Authors: Y Higuchi, S Nakamura, S Kigoshi, S Shoin
• Journal: Gan (Gan) Vol. 70 Issue 4 Pg. 447-51 (Aug 1979) ISSN: 0016-450X [Print] Japan
• PMID: 389727 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Biological Products
• Chromium Radioisotopes

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Biological Products (pharmacology)
• Carcinoma, Ehrlich Tumor (ultrastructure)
• Cell Survival (drug effects)
• Chromium Radioisotopes
• Isotope Labeling
• Mice
• Microscopy, Phase-Contrast
• Streptococcus (analysis)