Topical treatment of pressure ulcers. A randomized comparative trial of Varidase and zinc oxide.

Abstract

In a single-blind, randomized trial, the efficacy of topical streptokinase-streptodornase (Varidase) solution was compared with that of zinc oxide on necrotic pressure ulcers in 28 patients. The effectiveness was determined by measuring the necrosis removal within 8 weeks. This occurred in 6 patients (43%) treated with Varidase and in 7 (50%) treated with zinc oxide. The statistical tests applied showed no significant difference between the two treatments despite the use of a high power (1-beta = 0.95). The data suggest that the two regimens are about equally effective in the treatment of necrotic tissue.

• Authors: M S Agren, H E Strömberg
• Journal: Scandinavian journal of plastic and reconstructive surgery (Scand J Plast Reconstr Surg) Vol. 19 Issue 1 Pg. 97-100 ( 1985) ISSN: 0036-5556 [Print] Sweden
• PMID: 3895409 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Isotonic Solutions
• Streptodornase and Streptokinase
• Zinc
• Zinc Oxide

Topics

• Aged
• Bandages
• Clinical Trials as Topic
• Female
• Humans
• Isotonic Solutions
• Male
• Middle Aged
• Pressure Ulcer (drug therapy)
• Random Allocation
• Streptodornase and Streptokinase (administration & dosage)
• Zinc (administration & dosage)
• Zinc Oxide (administration & dosage)