Comparison of single-dose vs one-week course of metronidazole for symptomatic bacterial vaginosis.

Abstract

In a prospective, single-blind, randomized study, a single 2-g dose of metronidazole was compared with a seven-day course of 500 mg given twice daily in the treatment of symptomatic vaginal discharge associated with Gardnerella vaginalis. Based on resolution of symptoms and on cultures negative for G vaginalis, 86% (40/46) of women treated with the single dose and 97% (35/36) of women treated with the seven-day course were considered cured at seven to ten days after treatment. Evaluation at 21 days after treatment, however, indicated that only 46% (16/34) of patients treated with the single 2-g dose were considered cured compared with 86% (26/30) of those treated with the seven-day course. Treatment of sexual contacts did not significantly improve cure rates in either group.

• Authors: J Swedberg, J F Steiner, F Deiss, S Steiner, D A Driggers
• Journal: JAMA (JAMA) 1985 Aug 23-30 Vol. 254 Issue 8 Pg. 1046-9 ISSN: 0098-7484 [Print] United States
• PMID: 3894707 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Metronidazole

Topics

• Adolescent
• Adult
• Bacteriological Techniques
• Drug Administration Schedule
• Female
• Gardnerella vaginalis (isolation & purification)
• Haemophilus Infections (drug therapy)
• Humans
• Male
• Metronidazole (administration & dosage, adverse effects)
• Middle Aged
• Random Allocation
• Sexual Behavior
• Vaginitis (drug therapy, microbiology)