HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Multiple cotton wool spots following bone marrow transplantation for treatment of acute lymphatic leukaemia.

Abstract
Three patients with acute lymphatic leukaemia developed visual impairment due to occlusion of small retinal vessels with multiple cotton wool spots after treatment which included whole body and skull irradiation followed by bone marrow transplantation and cyclosporin A. Withdrawal of cyclosporin A and treatment with corticosteroids was followed by recovery of visual acuity. This retinopathy and the retinal changes seen in the immunodeficiency syndrome are thought to be closely related. The possible role of cyclosporin A is discussed, though cotton wool spots and retinal haemorrhages have never been described in renal transplant patients during treatment with this drug. Withdrawal of cyclosporin A, which is highly effective in preventing graft-versus-host disease, can be fatal. Irradiation of the skull prior to bone marrow transplantation and intrathecal administration of methotrexate may be the most important factors causing the retinal ischaemic signs described here. The inclusion of an ophthalmologist in the team monitoring transplant patients would lead to increased documentation and a better understanding of this disease.
AuthorsB Gloor, A Gratwohl, H Hahn, S Kretzschmar, Y Robert, B Speck, B Daicker
JournalThe British journal of ophthalmology (Br J Ophthalmol) Vol. 69 Issue 5 Pg. 320-5 (May 1985) ISSN: 0007-1161 [Print] England
PMID3888252 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cyclosporins
Topics
  • Adult
  • Bone Marrow Transplantation
  • Cyclosporins (adverse effects, therapeutic use)
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Leukemia, Lymphoid (therapy)
  • Male
  • Retinal Diseases (chemically induced, etiology, pathology)
  • Retinal Vessels

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: