Abstract |
Eight patients with severe aplastic anemia (SAA) and two patients with congenital hypoplastic anemia (CHA) were treated with absorbed samples of rabbit anti-thymocyte globulin (ATG) at a total dose of 50-75 mg/kg body weight intravenously over 5 days. Duration of the disease was 1-14 years. Median age of the ten patients was 11 (4-15) years. Four of the eight patients with SAA were responders and transfusion independent for a follow up of 11 to 50 months. In two cases thrombocytopenia of about 100 000/mm3 is present. Four patients were non-responders three of them died in the meantime by the underlining disease. Two patients with CHA did not respond to ATG treatment. The CFU-C level of all eight patients with SAA before treatment was severely decreased. In co-culture studies with normal bone marrow no growth inhibition of normal bone marrow could be demonstrated. Also 20% patients serum did not inhibit normal bone marrow growth. The results are compared with data from literature and discussed in respect to alternative therapies.
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Authors | R J Haas, B Netzel, G Meyer, W Huber, H Manz |
Journal | Klinische Padiatrie
(Klin Padiatr)
1985 Mar-Apr
Vol. 197
Issue 2
Pg. 101-5
ISSN: 0300-8630 [Print] Germany |
Vernacular Title | Anti-Thymozyten-Globulin Therapie bei schwerer aplastischer Anämie: eine Alternative zur Knochenmarkstransplantation. |
PMID | 3887011
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Isoantibodies
- anti-Thy antibody
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Topics |
- Adolescent
- Anemia, Aplastic
(therapy)
- Blood Transfusion
- Bone Marrow Transplantation
- Child
- Child, Preschool
- Colony-Forming Units Assay
- Combined Modality Therapy
- Erythrocyte Transfusion
- Female
- Follow-Up Studies
- Graft Rejection
- Humans
- Isoantibodies
(adverse effects, therapeutic use)
- Male
- Platelet Transfusion
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