HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Anti-thymocyte globulin therapy in severe aplastic anemia: an alternative to bone marrow transplantation].

Abstract
Eight patients with severe aplastic anemia (SAA) and two patients with congenital hypoplastic anemia (CHA) were treated with absorbed samples of rabbit anti-thymocyte globulin (ATG) at a total dose of 50-75 mg/kg body weight intravenously over 5 days. Duration of the disease was 1-14 years. Median age of the ten patients was 11 (4-15) years. Four of the eight patients with SAA were responders and transfusion independent for a follow up of 11 to 50 months. In two cases thrombocytopenia of about 100 000/mm3 is present. Four patients were non-responders three of them died in the meantime by the underlining disease. Two patients with CHA did not respond to ATG treatment. The CFU-C level of all eight patients with SAA before treatment was severely decreased. In co-culture studies with normal bone marrow no growth inhibition of normal bone marrow could be demonstrated. Also 20% patients serum did not inhibit normal bone marrow growth. The results are compared with data from literature and discussed in respect to alternative therapies.
AuthorsR J Haas, B Netzel, G Meyer, W Huber, H Manz
JournalKlinische Padiatrie (Klin Padiatr) 1985 Mar-Apr Vol. 197 Issue 2 Pg. 101-5 ISSN: 0300-8630 [Print] Germany
Vernacular TitleAnti-Thymozyten-Globulin Therapie bei schwerer aplastischer Anämie: eine Alternative zur Knochenmarkstransplantation.
PMID3887011 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Isoantibodies
  • anti-Thy antibody
Topics
  • Adolescent
  • Anemia, Aplastic (therapy)
  • Blood Transfusion
  • Bone Marrow Transplantation
  • Child
  • Child, Preschool
  • Colony-Forming Units Assay
  • Combined Modality Therapy
  • Erythrocyte Transfusion
  • Female
  • Follow-Up Studies
  • Graft Rejection
  • Humans
  • Isoantibodies (adverse effects, therapeutic use)
  • Male
  • Platelet Transfusion

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: