Single-dose antibiotic prophylaxis in high-risk patients undergoing cesarean section.

Abstract

A prospective, double-blind, placebo-controlled study was performed to determine the effectiveness of single-dose antibiotic prophylaxis in decreasing infectious complications after primary cesarean section. One hundred women at high risk for postoperative infectious morbidity were randomly assigned to receive either placebo or one 2-g dose of ceftizoxime at cord clamping. The incidence of endometritis in the antibiotic group was 6.0 versus 24.5% in the placebo group (P less than .05). The incidence of febrile morbidity in the group receiving one dose of ceftizoxime was 14.0 versus 32.7% in the placebo group (P less than .05). Single-dose ceftizoxime prophylaxis significantly reduced the incidence of endometritis and febrile morbidity in high-risk patients undergoing cesarean section.

• Authors: D H Saltzman, L J Eron, H H Kay, J G Sites
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 65 Issue 5 Pg. 655-7 (May 1985) ISSN: 0029-7844 [Print] United States
• PMID: 3885107 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Ceftizoxime
• Cefotaxime

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Cefotaxime (administration & dosage, analogs & derivatives, therapeutic use)
• Ceftizoxime
• Cesarean Section
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Postoperative Complications (prevention & control)
• Pregnancy
• Premedication
• Puerperal Infection (prevention & control)
• Risk