The effectiveness of glycosaminoglycans in peripheral vascular disease therapy: a clinical and experimental trial.

Abstract

Thirty patients suffering from peripheral vascular disease (stage-II according to Fontaine) were included in a double-blind study aimed at assessing the efficacy of a high-dose glycosaminoglycan (GAG) (Sulodexide) both in terms of laboratory parameters, such as lipid metabolism and blood coagulation components, and instrumental procedures (strain-gauge plethysmography). Compared with the fifteen control patients (treated with placebo), the fifteen patients treated with Sulodexide showed a significant decrease in blood triglycerides and fibrinogen as well as a significantly increased HDL-cholesterol, and positive instrumental changes: at the end of treatment Peak and Rest Flow values--and consequently also Winsor's index--were significantly increased only in patients treated with Sulodexide.

• Authors: C Corsi, L Bocci, C Cipriani, A Gazzini, E Marrapodi
• Journal: The Journal of international medical research (J Int Med Res) Vol. 13 Issue 1 Pg. 40-7 ( 1985) ISSN: 0300-0605 [Print] England
• PMID: 3884410 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Cholesterol, HDL
• Glycosaminoglycans
• Triglycerides
• glucuronyl glucosamine glycan sulfate
• Fibrinogen

Topics

• Aged
• Arteriosclerosis (drug therapy)
• Cholesterol, HDL (blood)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Femoral Artery
• Fibrinogen (metabolism)
• Glycosaminoglycans (administration & dosage, therapeutic use)
• Humans
• Intermittent Claudication (drug therapy)
• Male
• Random Allocation
• Triglycerides (blood)
• Vascular Diseases (drug therapy)