Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses.

In mouse cells carrying the dominant influenza resistance allele Mx+ (but not in Mx- cells) interferon-alpha/beta (IFN) induces an efficient antiviral state against influenza viruses and, concomitantly, the synthesis of a 75,000-Da protein (protein Mx). Here, indirect immunofluorescence using monoclonal antibodies was used to demonstrate that protein Mx accumulates in the nucleus of IFN-treated Mx+ cells, suggesting a nuclear site of action. Protein Mx is present in the nucleus of untreated influenza virus-resistant macrophages freshly explanted from the peritoneal cavity of Mx+ mice but is lost with time in culture when peritoneal macrophages become permissive for influenza virus.
AuthorsP Dreiding, P Staeheli, O Haller
JournalVirology (Virology) Vol. 140 Issue 1 Pg. 192-6 (Jan 15 1985) ISSN: 0042-6822 [Print] UNITED STATES
PMID3880978 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Interferon Type I
  • Mx1 protein, mouse
  • Myxovirus Resistance Proteins
  • Proteins
  • GTP-Binding Proteins
  • Alleles
  • Animals
  • Antibodies, Monoclonal
  • Cell Nucleus (metabolism)
  • Fluorescent Antibody Technique
  • GTP-Binding Proteins
  • Immunity, Innate
  • Interferon Type I (immunology)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Myxovirus Resistance Proteins
  • Orthomyxoviridae (immunology)
  • Proteins (genetics)
  • Species Specificity

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