Abstract |
Epidermal growth factor ( EGF) was assayed radioimmunologically in three secretions of the human mammary gland: milk (n = 16), colostrum (n = 8) and breast cyst fluid (n = 139). The immunoreactivity (immunoreactive EGF) detected in these three fluids corresponds directly to monomeric EGF, as can be shown by the complete cross-reaction with the standard and the identical behaviour in chromatography on Sephadex G50. The mean concentration of EGF is significantly greater in breast cyst fluid (241 +/- 143 ng/ml) and in colostrum (197 +/- 56 ng/ml) than in milk (107 +/- 22 ng/ml). The range of individual values in cyst fluid is large, 5-945 ng/ml. A possible role of EGF as a paracrine or autocrine factor in the pathology of cystic dysplasia of the mammary gland and in the increased risk of malignant transformation is hypothesised.
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Authors | J M Jaspar, P Franchimont |
Journal | European journal of cancer & clinical oncology
(Eur J Cancer Clin Oncol)
Vol. 21
Issue 11
Pg. 1343-8
(Nov 1985)
ISSN: 0277-5379 [Print] England |
PMID | 3878296
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Binding, Competitive
- Breast Diseases
(metabolism)
- Chromatography, Gel
- Colostrum
(analysis)
- Cross Reactions
- Cysts
(metabolism)
- Epidermal Growth Factor
(analysis, urine)
- Female
- Humans
- Milk, Human
(analysis)
- Radioimmunoassay
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