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Radioimmunoassay of human epidermal growth factor in human breast cyst fluid.

Abstract
Epidermal growth factor (EGF) was assayed radioimmunologically in three secretions of the human mammary gland: milk (n = 16), colostrum (n = 8) and breast cyst fluid (n = 139). The immunoreactivity (immunoreactive EGF) detected in these three fluids corresponds directly to monomeric EGF, as can be shown by the complete cross-reaction with the standard and the identical behaviour in chromatography on Sephadex G50. The mean concentration of EGF is significantly greater in breast cyst fluid (241 +/- 143 ng/ml) and in colostrum (197 +/- 56 ng/ml) than in milk (107 +/- 22 ng/ml). The range of individual values in cyst fluid is large, 5-945 ng/ml. A possible role of EGF as a paracrine or autocrine factor in the pathology of cystic dysplasia of the mammary gland and in the increased risk of malignant transformation is hypothesised.
AuthorsJ M Jaspar, P Franchimont
JournalEuropean journal of cancer & clinical oncology (Eur J Cancer Clin Oncol) Vol. 21 Issue 11 Pg. 1343-8 (Nov 1985) ISSN: 0277-5379 [Print] England
PMID3878296 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Epidermal Growth Factor
Topics
  • Binding, Competitive
  • Breast Diseases (metabolism)
  • Chromatography, Gel
  • Colostrum (analysis)
  • Cross Reactions
  • Cysts (metabolism)
  • Epidermal Growth Factor (analysis, urine)
  • Female
  • Humans
  • Milk, Human (analysis)
  • Radioimmunoassay

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