Cutaneous T-cell lymphoma presenting as a rapidly enlarging ocular adnexal tumor.

A 63-year-old man, in good health previously, developed swelling and erythema of the right upper eyelid which progressed to involve both eyelids and surrounding tissues. After one month, he had a 9.0 x 9.0 x 3.5 cm mass despite two attempts at incisional drainage and treatment with antibiotics. Multiple asymptomatic erythematosus nodules (2-3 cm in diameter) developed on his back, trunk, and arms four weeks after onset of the eyelid erythema and swelling. Biopsies of two upper back papules and the eyelid disclosed cutaneous T-cell lymphoma, a lymphoproliferative malignancy of thymus derived lymphocytes originating in the skin. Systemic chemotherapy resulted in a marked decrease in the ocular adnexal mass but lymphomatous meningitis and quadriplegia developed. The patient died four months later; an autopsy was not performed. This case demonstrates that cutaneous T-cell lymphoma may rarely have its initial manifestation as a rapidly enlarging eyelid tumor.
AuthorsB Meekins, A D Proia, G K Klintworth
JournalOphthalmology (Ophthalmology) Vol. 92 Issue 9 Pg. 1288-93 (Sep 1985) ISSN: 0161-6420 [Print] UNITED STATES
PMID3877264 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Eyelid Neoplasms (drug therapy, etiology, pathology)
  • Humans
  • Lymphoma (complications, drug therapy, pathology)
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Skin Neoplasms (complications, drug therapy, pathology)
  • T-Lymphocytes (ultrastructure)

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