Neuroendocrine study of a male infant with septo-optic dysplasia.

Abstract

Septo-optic dysplasia includes abnormalities of the optic nerves and tracts with absence of the septum pellucidum. Most of the recently reported patients were deficient in growth hormone. We describe a male infant with septo-optic dysplasia in whom extensive endocrine evaluation revealed central diabetes insipidus, hypothalamic hypothyroidism and combined (hypothalamic-pituitary) hypoadrenalism, along with normal pituitary growth hormone reserve. This is the first reported case of a patient with septo-optic dysplasia who underwent corticotropin-releasing factor and growth hormone-releasing hormone stimulation.

• Authors: L Sirota, Z Dickerman, Z Laron, R Weitz, F Dulitzky
• Journal: Israel journal of medical sciences (Isr J Med Sci) Vol. 21 Issue 9 Pg. 745-9 (Sep 1985) ISSN: 0021-2180 [Print] Israel
• PMID: 3877029 (Publication Type: Case Reports, Journal Article)

Topics

• Adrenal Glands (physiopathology)
• Adrenal Insufficiency (complications, physiopathology)
• Adult
• Cerebral Ventricles (abnormalities)
• Cerebral Ventriculography
• Diabetes Insipidus (complications, physiopathology)
• Female
• Humans
• Hypothalamo-Hypophyseal System (physiopathology)
• Hypothyroidism (complications, physiopathology)
• Infant, Newborn
• Male
• Optic Nerve (abnormalities, pathology)
• Septum Pellucidum (abnormalities, diagnostic imaging)
• Syndrome
• Tomography, X-Ray Computed